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4-Methoxy 17β-Estradiol
CAS No. 26788-23-8
4-Methoxy 17β-Estradiol( )
Catalog No. M28698 CAS No. 26788-23-8
4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.
4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Name4-Methoxy 17β-Estradiol
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NoteResearch use only, not for human use.
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Brief Description4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.
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Description4-Methoxy-17-estradiol is one of the estrogen metabolites and a methylation metabolite of 4-hydroxyestradiol.(In Vitro):4-Methoxy-17-estradiol treatment significantly decreased cell growth and increased mitotic index. Elevation of ROS and SOD activity, with a concomitant decrease in the intracellular GSH/GSSG ratio, was also detected in 4-Methoxy-17-estradiol-treated cells. Quantitative comet assay showed increased oxidative DNA damage in the 4-Methoxy-17-estradiol-treated H1355 cells, which could be significantly reduced by the anti-oxidant N-acetylcysteine (NAC).(In Vivo):4-Methoxy-17-estradiol had much weaker estrogenic activity and have similar lipid-modulating effects compared to 4-hydroxyestradiol in ovariectomized female rats.
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In Vitro
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In Vivo
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Synonyms
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PathwayOthers
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TargetOther Targets
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RecptorHDAC2| HDAC6
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Research Area
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Indication
Chemical Information
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CAS Number26788-23-8
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Formula Weight302.41
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Molecular FormulaC19H26O3
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Purity>98% (HPLC)
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Solubility
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SMILESC[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1c(cc1)c3c(OC)c1O)[C@H]2O
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Chemical Name
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yodita Asfaha, et al. Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells. Bioorg Med Chem. 2020 Jan 1;28(1):115108.
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